The science
Korean exosome science, an academic foundation.
The Exotokine line is developed by BAE Lab, a stem-cell research laboratory founded in 2018 at Soongsil University, Seoul — built on a patented EV membrane filter and bio-inspired, nano-defined cell culture.
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BAE Lab / Soongsil University research imagery
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The terms
Exosomes and PDRN, in plain terms.
What is an exosome?
An exosome is a nanoscale vesicle that carries active molecules — RNA, proteins, peptides — between cells. In skincare, exosomes act as a delivery vehicle that ferries actives across the skin barrier. Exotokine uses 100% plant-derived exosomes from Centella Asiatica — no animal or human origin.
What is PDRN?
PDRN (polydeoxyribonucleotide) is a DNA-fragment active that activates the A2A receptor to drive tissue regeneration and calm inflammation. Pidiroenne uses plant-sourced Stable-PN PDRN from Rose & Soy — differentiated from common salmon-derived PDRN.
BAE Lab
Soongsil University, Seoul, Korea
Led by Prof. Won-Gyu Bae — PhD, Seoul National University; Post-Doctorate, Stanford University. A research house dedicated to beauty and medical products based on biomimetics.
- Founded 2018 — stem-cell research laboratory
- Patented EV Membrane Filter (multi-stage micro/nano)
- Bio-inspired, nano-defined cell culture
- Stable-PN technology for PDRN formulation
- Certifications: ISO, CPNP (EU), GCC, UK-compliant
- Distributed in the Balkans by Allure Beauty
Three technologies
One botanical system, three mechanisms.
Plant exosome technology
BAE Lab’s patented multi-stage micro/nano membrane filtration extracts extracellular vesicles from Centella Asiatica at 0.1% purity — the delivery vehicle behind Exotokine and Exotokine Black.
Stable-PN PDRN
A plant-sourced polydeoxyribonucleotide from Amber Rose & Soy — differentiated from common salmon PDRN, without fish-protein allergy or animal-origin concerns. The core active behind Pidiroenne.
Multivitamin delivery
Tocoforte formulates Vitamins C, E, B3 and B5 for transdermal, in-clinic delivery — the difference between a vitamin product and a vitamin result.
Why botanical
Plant-based exosomes vs. animal-derived products.
| Parameter | Animal exosomes | Exotokine (plant-based) |
|---|---|---|
| Source | Animal stem cells | Centella Asiatica (100% plant) |
| Ethical concerns | Animal welfare | No ethical production concerns |
| Contamination | Viral / prion transmission risk | No human / animal pathogen risk |
| Stability | Variable (donor-dependent) | Stable (controlled culture) |
| Regulatory | Stricter for human origin | EU / GCC cosmetic compliant |
In-vitro evidence
Measured, not marketed.
- · PP-Exosome heals wounds faster than control groups.
- · Increased macrophage recruitment (Iba-1).
- · Enhanced angiogenesis (α-SMA on day 14).
- · PDRN increases fibroblasts at 20–100 µg/ml; stimulates VEGF.
- · Documented 22-day wound recovery with Exotokine + Pidiroenne.
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In-vitro / clinical evidence figure
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